In 1946 Paul Halmos studied unbiased estimators of minimum variance, and planted the seed from which the subject matter of the present monograph sprang. The author has undertaken to provide experts and advanced students with a review of the present status of the evolved theory of U-statistics, and

For fans of Oliver Sacks and Henry Marsh, a glimpse into the fascinating world of modern neurology by a leading expert in the field. As a trainee doctor, Andrew Lees was enthralled by his mentors: esteemed neurologists who combined the precision of mathematicians, the scrupulosity of entomologists and the solemnity of undertakers in their diagnoses and treatments. For them, there was no such thing as an unexplained symptom or psychosomatic problem-no difficult cases, only interesting ones-and it was only a matter of time before all disorders of the brain would be understood in terms of anatomical, electrical, and chemical connections. Today, this kind of "holistic neurology" is on the brink of extinction as a slavish adherence to protocols and algorithms-plus a worship of machines-runs the risk of destroying the key foundational clinical skills of listening, observation and imagination that have been at the heart of the discipline for over 150 years. In this series of brilliant, insightful, and autobiographical essays, Andrew Lees takes us on a kind of Sherlock Holmes tour of neurology, giving the reader insight into-and a defense of-the deep analytical tools that the best neurologists still rely on to diagnose patients: to heal minds and to fix brains.

In 1946 Paul Halmos studied unbiased estimators of minimum variance, and planted the seed from which the subject matter of the present monograph sprang. The author has undertaken to provide experts and advanced students with a review of the present status of the evolved theory of U-statistics, and

As a boy growing up near Liverpool in the 1950s, Andrew Lees would visit the docks with his father to watch the ships from Brazil unload their exotic cargo of coffee, cotton bales, molasses, cocoa - the ships' names and goods noted down in loving detail in his exercise book. One day, his father gave him a dog-eared book called Exploration Fawcett. The book told the true story of Lieutenant-Colonel Percy Fawcett, a British explorer who in 1925 had gone in search of a lost city in the Amazon, and never returned. The riveting story of Fawcett's encounters with deadly animals and hostile tribes, his mission to discover an Atlantean civilization, and the many who lost their own lives when they went in search of him, inspired the young Lees to believe that there were still earthly places where one could 'fall off the edge'.Lees travelled to Manaus in Fawcett's footsteps. After a time-bending psychedelic experience in the forest, he understood that his yearning for the imaginary Brazil of his boyhood, like Fawcett's search for an earthly paradise, was a nostalgia for what never was. Part travelogue, part memoir, Lees paints a portrait of an elusive Brazil, and a flawed explorer whose doomed mission ruined lives.

Lees draws on Burroughs' search for an addiction cure to discover a ground-breaking treatment for shaking palsy, and learns how to use the deductive reasoning of Sherlock Holmes to diagnose patients. Lees follows Burroughs into the rainforest and under the influence of yage (ayahuasca) gains insights that encourage him to pursue new lines of pharmacological research and explore new forms of science.

Emanating from a special National Preservation Conference, leading experts present 33 essays on future trends in the historic preservation field. Topics range from cultural diversity to the future of American communities. This book will guide preservations and anyone concerned about our built environment into the next quarter century.